Analysis Tools
nervous system
|
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females
|
behavior/neurological
|
• poor retention latency exhibited in light-dark step through box
|
|
• escape latencies across trial blocks in left-right discrimination learning are elevated and decrease little in comparison to decreased escape latencies exhibited in controls
• required higher trials to reach criterion and committed more errors in comparison to controls
|
|
• increased duration of immobility in Porsolt forced swim test
|
|
• increased irritability in response to touch escape test as compared to control
|
|
• poor nest building ability in comparison to controls
|
homeostasis/metabolism
|
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females
|
