Phenotypes Associated with This Genotype

Genotype
MGI:3718021

• Allelic Composition: Mfge8^tm1Mcu/Mfge8^tm1Mcu; Tg(RIP1-Tag)2Dh/?
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCr * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased metastatic potential ( J:123138 )

• there is a decrease in invasive type 2 tumors compared to in Tg(RIP1-Tag)2Dh transgenic mice

abnormal tumor morphology ( J:123138 )

• mice have a 20% reduction in tumor vessel permeability compared to in Tg(RIP1-Tag)2Dh transgenic mice

decreased tumor growth/size ( J:123138 )

• at 12 and 13.5 weeks of age, tumor burden is decreased 2-fold tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice

• tumor size and incidence is decreased compared to Tg(RIP1-Tag)2Dh transgenic mice

increased adenoma incidence ( J:123138 )

• adenoma incidence are increased compared to in Tg(RIP1-Tag)2Dh transgenic mice

• apoptotic cells are less frequent in adenomas compared to in hyperblastic and angiogenic islet cells in the same animals and in Tg(RIP1-Tag)2Dh transgenic mice

increased carcinoma incidence ( J:123138 )

• there is a two-fold increase in apoptosis in microinvasive carcinomas

hematopoietic system

decreased Langerhans cell number ( J:123138 )

• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice

• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice

• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice

immune system

decreased Langerhans cell number ( J:123138 )

• the number of angiogenic islets is decreased by 35% compared to in Tg(RIP1-Tag)2Dh transgenic mice

• proliferation of angiogenic islets is decreased by 25% compared to in Tg(RIP1-Tag)2Dh transgenic mice

• hyperplastic and angiogenic islet apoptosis is increased compared to in Tg(RIP1-Tag)2Dh transgenic mice