Phenotypes Associated with This Genotype

Genotype
MGI:3718008

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(Eno2-APOE_i4)1Rabr/0
• Genetic Background: involves: 129P2/OlaHsd * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:101973 )

• in the elevated-plus maze, mice show increased anxiety with reduced time and distance moved in the open arms; mice have significantly lower number of open-arm entries than wild-type

increased startle reflex ( J:101973 )

• response is higher in mice at 6 months of age compared to wild-type or Tg(Eno2-APOE*3)1Rabr/Apoe^tm1Unc mice but lower than Apoe^tm1Unc single mutants

nervous system

abnormal dendrite morphology ( J:101973 )

• mutants have lower levels of MAP 2-positive neuronal dendrites than wild-type; at 3 months, levels are similar in mutants and controls