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Phenotypes Associated with This Genotype
Genotype
MGI:3718003
Allelic
Composition		 Cdc25atm1Kiyo/Cdc25a+
Tg(MMTV-Erbb2)NK1Mul/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25atm1Kiyo mutation (0 available); any Cdc25a mutation (34 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of induced tumors ( J:123144 )
• mice develop tumors at a latency of 32 weeks compared to 23 weeks in Tg(MMTV-Erbb2)NK1Mul transgenic mice
• mice do not develop hyperplastic nodules in mammary glands as do Tg(MMTV-Erbb2)NK1Mul transgenic mice

cellular
decreased cell proliferation ( J:123144 )
• fewer cells are in S-phase and proliferation is decreased compared to in Tg(MMTV-Erbb2)NK1Mul transgenic mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory