Phenotypes Associated with This Genotype

Genotype
MGI:3717918

• Allelic Composition: Sox17^tm1Sjm/Sox17^tm1Sjm
• Genetic Background: BKa.129-Sox17^tm1Sjm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:123050 )

• expected numbers of homozygotes are found at E12.5, but complete lethality is observed by E13.5

embryo

abnormal embryo turning ( J:123050 )

• body axis rotation defects are observed by E11.5

abnormal rostral-caudal axis patterning ( J:123050 )

• at E11.5, embryos show severe defects in posterior patterning

embryonic growth retardation ( J:123050 )

• mice exhibit severe growth retardation by E11.5 compared to controls

abnormal embryonic hematopoiesis ( J:123050 )

• hematopoietic and erythroid cells are significantly reduced in the yolk sac and embryo at E11.5

hematopoietic system

abnormal embryonic hematopoiesis ( J:123050 )

• hematopoietic and erythroid cells are significantly reduced in the yolk sac and embryo at E11.5

decreased hematopoietic stem cell number ( J:123050 )

liver/biliary system

liver hypoplasia ( J:123050 )

• at E12.5, livers of homozygotes are extremely hypocellular

growth/size/body

embryonic growth retardation ( J:123050 )

• mice exhibit severe growth retardation by E11.5 compared to controls