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Phenotypes Associated with This Genotype
Genotype
MGI:3717918
Allelic
Composition
Sox17tm1Sjm/Sox17tm1Sjm
Genetic
Background
BKa.129-Sox17tm1Sjm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expected numbers of homozygotes are found at E12.5, but complete lethality is observed by E13.5

embryo
• body axis rotation defects are observed by E11.5
• at E11.5, embryos show severe defects in posterior patterning
• mice exhibit severe growth retardation by E11.5 compared to controls
• hematopoietic and erythroid cells are significantly reduced in the yolk sac and embryo at E11.5

hematopoietic system
• hematopoietic and erythroid cells are significantly reduced in the yolk sac and embryo at E11.5

liver/biliary system
• at E12.5, livers of homozygotes are extremely hypocellular

growth/size/body
• mice exhibit severe growth retardation by E11.5 compared to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory