Phenotypes Associated with This Genotype

Genotype
MGI:3717902

• Allelic Composition: Tg(KRT14-rtTA)208Jek/Y; Tg(tetO-KLF4)32831Rup/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

sebaceous gland atrophy ( J:96886 )

♂ • 9 days of doxycycline treatment to induce KLF4 expression, gland atrophy is observed

abnormal coat appearance ( J:96886 )

♂ • thinning of the pelage of the ventral skin is seen after 3-4 weeks of treatment with doxycycline

hair follicle degeneration ( J:96886 )

♂ • 9 days of doxycycline treatment to induce KLF4 expression, cystic degeneration of hair follicles is seen

abnormal skin morphology ( J:96886 )

♂ • in males, dysplastic phenotype is largely restricted to the ventral skin; dorsal skin is only mildly affected

♂ • females homozygous for Tg(KRT14-rtTA)208Jek display focal changes including cystic follicles and mild changes in the adjacent interfollicular epithelium after 4 weeks of induction

♂ • delayed squamous epithelium maturation is observed after 3-4 weeks of doxycycline treatment in males

abnormal epidermal layer morphology ( J:96886 )

♂ • hyperplastic, keratinizing epithelium extends into the dermis

abnormal epidermis stratum basale morphology ( J:96886 )

♂ • loss of basal cell polarity seen after 3-4 weeks of doxycycline treatment

hyperkeratosis ( J:96886 )

♂ • 9 days of doxycycline treatment to induce KLF4 expression, mouse skin shows hyperkeratosis

epidermal hyperplasia ( J:96886 )

♂ • 9 days of doxycycline treatment to induce KLF4 expression, epidermal hyperplasia is observed

skin lesions ( J:96886 )

♂ • crusted skin lesions are evident after 3-4 weeks of doxycycline treatment

endocrine/exocrine glands

sebaceous gland atrophy ( J:96886 )

♂ • 9 days of doxycycline treatment to induce KLF4 expression, gland atrophy is observed