Phenotypes Associated with This Genotype

Genotype
MGI:3717873

• Allelic Composition: Tg(MMTV-KLF4)1Rup/0; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6NTac * FVB/NJ * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:96886 )

• lifespan is ~8 months due to sarcomas

neoplasm

increased sarcoma incidence ( J:96886 )

• all mice develop sarcoma outgrowth within the fibrovascular response

• tumors 1-1.5 cm in diameter and are composed of spindled, anaplastic cells and scattered giant cells

integument

abnormal skin morphology ( J:96886 )

• vascular, fibrotic dermis

abnormal dermal layer morphology ( J:96886 )

skin lesions ( J:96886 )

• between 6 and 8 months of age, dorsal skin lesions similar to those in the inducible models develop in all animals