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Phenotypes Associated with This Genotype
Genotype
MGI:3717713
Allelic
Composition		 Sdc1tm1Cma/Sdc1tm1Cma
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sdc1tm1Cma mutation (0 available); any Sdc1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG1 level ( J:107378 )
• following infection with Trichinella spiralis, IgG1 production is reduced
decreased interleukin-10 secretion ( J:107378 )
• following infection with Trichinella spiralis, IL-10 production is reduced
decreased interleukin-13 secretion ( J:107378 )
• following infection with Trichinella spiralis, IL-13 production is reduced
increased susceptibility to parasitic infection ( J:107378 )
• following infection with Trichinella spiralis, IL-10, IL-13 and IgG1 production is reduced

hematopoietic system
decreased IgG1 level ( J:107378 )
• following infection with Trichinella spiralis, IgG1 production is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory