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Phenotypes Associated with This Genotype
Genotype
MGI:3717709
Allelic
Composition
Serpine2tm1Dmn/Serpine2tm1Dmn
Tg(Thy1-Serpine2)2Dmn/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpine2tm1Dmn mutation (0 available); any Serpine2 mutation (26 available)
Tg(Thy1-Serpine2)2Dmn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• following crush damage, Schwann cell proliferation is decreased and apoptosis rates are increased
• following crush damage, Schwann cell proliferation is decreased

nervous system
• following crush damage, Schwann cell proliferation is decreased and apoptosis rates are increased
• following crush damage, Schwann cell proliferation is decreased
• at 12 days following sciatic nerve crush, axonal regeneration in the sciatic nerve in the triceps surae muscle is delayed
• responsiveness following injury is delayed and mice do not regain full use of their limb until 2 to 4 days later than wild-type mice
• following crush damage, Schwann cell proliferation is decreased and apoptosis rates are increased
• at 12 days following sciatic nerve crush, axonal regeneration in the sciatic nerve in the triceps surae muscle is delayed
• responsiveness following injury is delayed and mice do not regain full use of their limb until 2 to 4 days later than wild-type mice
• at 12 days following sciatic nerve crush, axonal regeneration in the sciatic nerve in the triceps surae muscle is delayed
• responsiveness following injury is delayed and mice do not regain full use of their limb until 2 to 4 days later than wild-type mice

homeostasis/metabolism
• at 12 days following sciatic nerve crush, axonal regeneration in the sciatic nerve in the triceps surae muscle is delayed
• responsiveness following injury is delayed and mice do not regain full use of their limb until 2 to 4 days later than wild-type mice
• following crush damage, Schwann cell proliferation is decreased and apoptosis rates are increased


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory