Phenotypes Associated with This Genotype

Genotype
MGI:3717686

• Allelic Composition: En1^{tm1(Otx2)Wrst}/En1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron morphology ( J:88192 )

ectopic dopaminergic neuron ( J:88192 )

• dopaminergic domain expanded posteriorly at E12.5, E15.5, and in adults

abnormal serotonergic neuron morphology ( J:88192 )

• serotonergic neuron domain is shifted caudally and reduced at E12.5, E15.5, and adults

• primarily affects the dorsal raphe

homeostasis/metabolism

increased dopamine level ( J:88192 )

• significantly increased concentrations in the striatum

decreased serotonin level ( J:88192 )

• serotonin concentration in the striatum is significantly reduced

behavior/neurological

increased locomotor activity ( J:88192 )

• enhanced locomotion in adults