Phenotypes Associated with This Genotype

Genotype
MGI:3717680

• Allelic Composition: Pde4d^tm1Mct/Pde4d^tm1Mct
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased cardiac muscle contractility ( J:96125 )

• mice have an increased contractile rate in response to isoproterenol compared to wild-type mice

• treatment with rolipram following isoproterenol does not further alter heart contraction as it does in wild-type mice

• pertussis toxin enhances heart rate in response to isoproterenol

muscle

increased cardiac muscle contractility ( J:96125 )

• mice have an increased contractile rate in response to isoproterenol compared to wild-type mice

• treatment with rolipram following isoproterenol does not further alter heart contraction as it does in wild-type mice

• pertussis toxin enhances heart rate in response to isoproterenol