Phenotypes Associated with This Genotype

Genotype
MGI:3717644

• Allelic Composition: Tg(Thy1-APPLon)2Vln/0; Tg(Thy1-PSEN1*A246E)2Vln/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:64209 )

• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months

• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months

homeostasis/metabolism

amyloidosis ( J:64209 )

amyloid beta deposits ( J:64209 )

• amyloid deposition occurs at 6-9 months in double mutants compared to 12-15 months in single APP transgenic mice; Abeta 42/Abeta 40 ratio is increased in young and aged mice with ratio of 3.11 at 15 months compared to 0.43 in Tg(Thy1-APP*V642I)2Vln mice at 6-9 months

• plaque-associated peptides are dramatically high in brains of double mutant mice aged 6-9 months