Phenotypes Associated with This Genotype

Genotype
MGI:3717578

• Allelic Composition: Tg(Thy1-APPLon)2Vln/0
• Genetic Background: (C57BL/6 x FVB/N)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:53800 )

N • in forced swim test and a visible platform paradigm, transgenic mice perform comparably to controls indicating normal motor abilities and motivation

abnormal spatial learning ( J:53800 )

• in Morris water maze test hidden platform tests, 3-6 month old mice show significantly longer escape latencies (measure of spatial learning and memory) than non-transgenic controls

• when platform is removed, 3-6 month old mutants spend less time crossing area of the platform's former location than controls, indicating impaired cognition