Phenotypes Associated with This Genotype

Genotype
MGI:3717420

• Allelic Composition: Pthlh^tm1Hmk/Pthlh^tm1Hmk; Tg(Col2a1-PTHLH)2Ecw/0; Tg(KRT14-PTHLH)7Wmp/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dental phenotype of Pthlh^tm1Hmk/Pthlh^tm1Hmk mice rescued with Tg(Col2a1-PTHLH)2Ecw and Tg(KRT14-PTHLH)7Wmp transgenes

mortality/aging

premature death ( J:50144 )

growth/size/body

long lower incisors ( J:50144 )

• malocclusion allows for unchecked growth of the lower incisors

malocclusion ( J:50144 )

• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors

• upper incisors remain partly occluded and are less affected

• however, incisors and molars erupt normally and on schedule

decreased body size ( J:50144 )

decreased body weight ( J:50144 )

skeleton

long lower incisors ( J:50144 )

• malocclusion allows for unchecked growth of the lower incisors

malocclusion ( J:50144 )

• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors

• upper incisors remain partly occluded and are less affected

• however, incisors and molars erupt normally and on schedule

short maxilla ( J:50144 )

• foreshortened maxilla

chondrodystrophy ( J:50144 )

• develop progressive chondrodystrophy

craniofacial

long lower incisors ( J:50144 )

• malocclusion allows for unchecked growth of the lower incisors

malocclusion ( J:50144 )

• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors

• upper incisors remain partly occluded and are less affected

• however, incisors and molars erupt normally and on schedule

short maxilla ( J:50144 )

• foreshortened maxilla