Phenotypes Associated with This Genotype

Genotype
MGI:3717269

• Allelic Composition: Pten^tm1Mak/Pten⁺
• Genetic Background: B6.129P2-Pten^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Embryonic defects in Pten^tm1Mak/Pten⁺

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:93530 )

• more than 30% die by E10.5

growth/size/body

decreased embryo size ( J:93530 )

• the majority of embryos are smaller but have normal body symmetry and development of most organ systems

embryo

failure of initiation of embryo turning ( J:93530 )

• majority of embryos remain unturned

decreased embryo size ( J:93530 )

• the majority of embryos are smaller but have normal body symmetry and development of most organ systems

abnormal embryonic tissue morphology ( J:93530 )

• severely affected (about 5%) embryos have little or no development of the major organ systems, including the heart and brachial arches

• severely affected (about 5%) embryos have asymmetrical head folds

open neural tube ( J:93530 )

• neural tube is open along the entire length of the embryo

kinked neural tube ( J:93530 )

• neural tube is kinked along the entire length of the embyo

enlarged allantois ( J:93530 )

abnormal placenta morphology ( J:93530 )

• the remaining 20% of moribound embryos display other placental abnormalities including disorganization of the spongiotrophoblast layer and limited invasion of the trophoblast layer by the chorion

failure of chorioallantoic fusion ( J:93530 )

• the allantois fails to fuse to the chorion at E9 in 80% of dying embryos

nervous system

open neural tube ( J:93530 )

• neural tube is open along the entire length of the embryo

kinked neural tube ( J:93530 )

• neural tube is kinked along the entire length of the embyo

neoplasm

increased tumor incidence ( J:93530 )

increased adrenal gland tumor incidence ( J:93530 )

increased lymphoma incidence ( J:93530 )

increased endometrial carcinoma incidence ( J:93530 )

♀

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:93530 )

reproductive system

increased endometrial carcinoma incidence ( J:93530 )

♀