behavior/neurological
• mice fail to develop a conditioned taste aversion behavior when saccharin followed by a LiCl injection was used
• however, mice avoid quinine to a similar extent as wild-type mice do
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• fear-related memory either through cued or contextual conditioning is disrupted
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• fear-related memory either through cued or contextual conditioning is disrupted
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• mice fail to develop long-term recognition memory
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• mice fail to demonstrate improved performance during the late acquisition stage as wild-type mice do in a Morris water maze
• mice are less precise in processing spatial information and less flexible in relearning
• spatial memory formation is impaired
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• mice freeze less in response to a cued or contextual conditioned fear stimuli
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nervous system
N |
• brain morphology is normal
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• early long term potential is enhanced
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• late phase long term potential is impaired
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