About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3717260
Allelic
Composition
Arctm1.1Kuhl/Arctm1.1Kuhl
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arctm1.1Kuhl mutation (0 available); any Arc mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice fail to develop a conditioned taste aversion behavior when saccharin followed by a LiCl injection was used
• however, mice avoid quinine to a similar extent as wild-type mice do
• fear-related memory either through cued or contextual conditioning is disrupted
• fear-related memory either through cued or contextual conditioning is disrupted
• mice fail to develop long-term recognition memory
• mice fail to demonstrate improved performance during the late acquisition stage as wild-type mice do in a Morris water maze
• mice are less precise in processing spatial information and less flexible in relearning
• spatial memory formation is impaired
• mice freeze less in response to a cued or contextual conditioned fear stimuli

nervous system
N
• brain morphology is normal
• early long term potential is enhanced
• late phase long term potential is impaired


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory