Phenotypes Associated with This Genotype

Genotype
MGI:3717226

• Allelic Composition: Tlr2^lngd/Tlr2^lngd
• Genetic Background: C57BL/6J-Tlr2^lngd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:94077 )

• mutant macrophages do not respond to diacyl or triacyl lipopeptides or other TLR2-dependent microbial signature molecules

increased susceptibility to bacterial infection ( J:94077 )

• mice are immunocompromised in response to Gram-positive bacterial infection

hematopoietic system

abnormal macrophage physiology ( J:94077 )

• mutant macrophages do not respond to diacyl or triacyl lipopeptides or other TLR2-dependent microbial signature molecules