Analysis Tools
mortality/aging
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• 37% of mice are recovered between E12 and P0 versus the expected 50%
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• 25% of the expected ratio of mice survive to weaning
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embryo
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• at E8.5 to E9, 50% of mice exhibit an allantois that is not yet fused to the chorion and that contains a densely packed mesenchymal core
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• at E8.5 to E9
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• at E8.5 to E9, 50% of mice exhibit an allantois that is not yet fused to the chorion and that contains a densely packed mesenchymal core
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skeleton
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• in 3 of 3 mice at E13.5 to P0
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limbs/digits/tail
polydactyly
(
J:108516
)
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• 1 in 12 mice display polydactyly at a similar frequency as in Bmp4tm1.1Jlch homozygotes
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• 8 of 12 mice exhibit forelimb postaxial duplications at a similar frequency as in Bmp4tm1.1Jlch homozygotes
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cardiovascular system
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• at E15 to E 17.5, 50% of mice exhibit a defect in closure of the membranous portion of the ventricular septum
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vision/eye
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• at E12 to P0, 13 of 22 mice have missing or smaller eyes
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anophthalmia
(
J:108516
)
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• at E12 to P0, 13 of 22 mice have missing or smaller eyes
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growth/size/body
omphalocele
(
J:108516
)
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• in 9 of 18 mice at E13.5 to P0
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• at E13.5 to P0, mice exhibit a variety of ventral body wall closure defects ranging from complete failure of ventral body wall fusion leading to the externalization of the viscera (in 5 of 18 mice), to umbilical hernia (in 9 of 18 mice) to the failure of sternal fusion leading to s split xiphoid process (in 3 of 3 mice)
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