Phenotypes Associated with This Genotype

Genotype
MGI:3717110

• Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:117491 )

• 46% of mice die by 3 weeks

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

abnormal neurocranium morphology ( J:117491 )

• 43% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• all homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal sternum morphology ( J:117491 )

• 43% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

abnormal vertebrae morphology ( J:117491 )

• 43% of mice have widened vertebral arches and forked vertebrae

abnormal vertebral arch morphology ( J:117491 )

• 43% of mice have widened vertebral arches and forked vertebrae

renal/urinary system

abnormal kidney morphology ( J:117491 )

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often degraded

• smooth muscle cell number is reduced in the glomeruli

• migration of smooth muscle cells in glomeruli is impaired

small kidney ( J:117491 )

pale kidney ( J:117491 )

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

growth/size/body

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

decreased body weight ( J:117491 )

postnatal growth retardation ( J:117491 )

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli

cellular

abnormal cell migration ( J:117491 )

• migration of smooth muscle cells in glomeruli is impaired

decreased fibroblast cell migration ( J:117491 )

• mouse embryonic fibroblast cells show reduced migration in a scratch test in response to PDGF stimulation

immune system

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

craniofacial

abnormal neurocranium morphology ( J:117491 )

• 43% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• all homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

digestive/alimentary system

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

respiratory system

short nasal bone ( J:117491 )