Phenotypes for Shc1 MGI:3717109 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Shc1^tm3Paw/Shc1^tm4Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm4Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• mice display more severe motor defects than transheterozygous Shc1^{tm4Paw/tm7Paw} mice

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls

• intrafusal fiber numbers are 66.6% of control numbers

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls

• intrafusal fiber numbers are 66.6% of control numbers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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