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Phenotypes Associated with This Genotype
Genotype
MGI:3717108
Allelic
Composition
Shc1tm3Paw/Shc1tm7Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm7Paw mutation (0 available); any Shc1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice display motor defects more severe than than transheterozygous Shc1tm3Paw/tm4Paw mice

nervous system
• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls
• intrafusal fiber numbers are 35.9% of control numbers

muscle
• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls
• intrafusal fiber numbers are 35.9% of control numbers


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory