Phenotypes for Myl1 Shc1 MGI:3717105 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm4Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm4Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• motor abnormalities are less severe, similar to those observed in Shc1^tm4Paw homozygotes

ataxia ( J:122927 )

muscle

abnormal muscle spindle morphology ( J:122927 )

• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

nervous system

abnormal muscle spindle morphology ( J:122927 )

• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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