Phenotypes Associated with This Genotype

Genotype
MGI:3717102

• Allelic Composition: Myl1^tm1(cre)Sjb/Myl1⁺; Shc1^tm9Paw/Shc1^tm9Paw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• all viable mice are severely uncoordinated, appearing similar to Shc1^tm4Paw homozygotes

ataxia ( J:122927 )

impaired limb coordination ( J:122927 )

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls

• intrafusal fiber numbers are 59% that of controls

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindle numbers are reduced 50% compared to controls

• intrafusal fiber numbers are 59% that of controls