Phenotypes for Shc1 Tg(Myh6-cre)2182Mds MGI:3717096 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Shc1^tm8Paw/Shc1^tm9.1Paw Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm8Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:122927 )

• between E12.5 and 13.5, 8/19 mutant embryos are dead, compared to all mutant embryos not expressing the cre-recombined allele; remaining embryos have regularly beating hearts and normal-appearing trabeculae

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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