Phenotypes Associated with This Genotype

Genotype
MGI:3717009

• Allelic Composition: Shc1^tm4Paw/Shc1^tm4Paw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:122927 )

• many embryos are dead at E11.5 (13/27), and no live embryos are found at E12.5

behavior/neurological

ataxia ( J:122927 )

• mice display less severe ataxia than Shc1^tm7Paw

nervous system

abnormal muscle spindle morphology ( J:122927 )

• total spindle numbers are normal but in mice at P2-P9 and in adults, intrafusal fiber numbers are 66.7 and 62.5% of contols numbers

abnormal nerve conduction ( J:122927 )

• synaptic conductivity of group Ia sensory neurons is impaired

abnormal excitatory postsynaptic potential ( J:122927 )

• amplitudes of short-latency EPSPs are smaller than in wild-type mice

muscle

abnormal myocardial trabeculae morphology ( J:122927 )

• cardiac trabeculae are poorly developed

abnormal muscle spindle morphology ( J:122927 )

• total spindle numbers are normal but in mice at P2-P9 and in adults, intrafusal fiber numbers are 66.7 and 62.5% of contols numbers

cardiovascular system

abnormal myocardial trabeculae morphology ( J:122927 )

• cardiac trabeculae are poorly developed

abnormal cardiovascular system physiology ( J:122927 )

• at E11.5, living embryos have irregularly beating hearts