Phenotypes Associated with This Genotype

Genotype
MGI:3716923

• Allelic Composition: Tns3^Gt(XK294)Byg/Tns3^Gt(XK294)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:96666 )

growth/size/body

decreased body weight ( J:96666 )

• 33% of mice are smaller than wild-type mice (4.8g compared to 8.4g at day 14)

postnatal growth retardation ( J:96666 )

• small mice die within 20 days of birth

digestive/alimentary system

abnormal digestive system morphology ( J:96666 )

• digestive tract is about half the length of that in wild-type mice

abnormal small intestinal villus morphology ( J:96666 )

• villi epithelial cells are irregular and the cytoplasm of individual cells is smaller than in wild-type mice

• enterocyte differentiation is defective

• migration of intestinal epithelial cells is defective

small stomach ( J:96666 )

respiratory system

abnormal lung morphology ( J:96666 )

• distal air spaces are enlarged

• more blood cells are found within the lungs than in wild-type mice

abnormal pulmonary alveolus morphology ( J:96666 )

• fewer septa are present

skeleton

decreased chondrocyte proliferation ( J:96666 )

• chondrocyte proliferation is reduced

abnormal long bone epiphyseal plate morphology ( J:96666 )

• the resting zone is enlarged

• however, proliferative and hypertropic zones are comparable to those in wild-type mice

abnormal bone marrow morphology ( J:96666 )

• more blood cells are found within bones compared to in wild-type bones

• bones are thinner than wild-type bones

hematopoietic system

small spleen ( J:96666 )

cellular

abnormal cell migration ( J:96666 )

• migration of intestinal epithelial cells is defective

decreased chondrocyte proliferation ( J:96666 )

• chondrocyte proliferation is reduced

immune system

small spleen ( J:96666 )