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Phenotypes Associated with This Genotype
Genotype
MGI:3716857
Allelic
Composition		 Krastm1Bbd/Kras+
Mapk14tm2Nbr/Mapk14+
Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation (2 available); any Kras mutation (88 available)
Mapk14tm2Nbr mutation (2 available); any Mapk14 mutation (43 available)
Polr2atm1(cre/ERT2)Bbd mutation (3 available); any Polr2a mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:122397 )
• mice live up to 40 weeks

neoplasm
increased hemolymphoid system tumor incidence ( J:122397 )
• by 24 weeks, mice develop tumors in the thymus
increased lung tumor incidence ( J:122397 )
• by 24 weeks, mice develop tumors in lungs
increased lung adenoma incidence ( J:122397 )
• at 4 weeks after 5-hydroxytamoxifen treatment, a few small adenomas are observed in some animals

respiratory system
increased lung tumor incidence ( J:122397 )
• by 24 weeks, mice develop tumors in lungs
increased lung adenoma incidence ( J:122397 )
• at 4 weeks after 5-hydroxytamoxifen treatment, a few small adenomas are observed in some animals

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory