Phenotypes Associated with This Genotype

Genotype
MGI:3716752

• Allelic Composition: Ambra1^{Gt(pGT1.8geo)1Fcec}/Ambra1^{Gt(pGT1.8geo)1Fcec}
• Genetic Background: involves: CD-1 * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:122795 )

• lethality is observed with homozygous embryos comprising only 14.7% of total embryos collected between E10.5 and E13.5; resorptions make up 6.5% of total embryos recovered, while wild-type and heterozygous embryos are found at near-Mendelian ratios

• at E12.5 and E13.5, 2 and 1 homozygous embryos are recovered

nervous system

spina bifida ( J:122795 )

• between E10-14.5, most embryos display spina bifida with or without accompanying midbrain/hindbrain exencephaly; 11/34 embryos have both exencephaly and spina bifida, while 2/34 exhibit only spina bifida

exencephaly ( J:122795 )

• between E10-14.5, embryos display midbrain/hindbrain exencephaly with or without accompanying spina bifida; 17/34 homozygotes exhibit exencephaly only, with 11/34 embryos displaying exencephaly and spina bifida

embryo

spina bifida ( J:122795 )

• between E10-14.5, most embryos display spina bifida with or without accompanying midbrain/hindbrain exencephaly; 11/34 embryos have both exencephaly and spina bifida, while 2/34 exhibit only spina bifida