Phenotypes Associated with This Genotype

Genotype
MGI:3716639

• Allelic Composition: Pink1^tm1Shn/Pink1^tm1Shn
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system physiology ( J:122728 )

• catecholamine release is lower than in wild-type mice

reduced long-term potentiation ( J:122728 )

• long term potential (LTP) induced by high frequency stimulation in the absence of magnesium is lower than in wild-type mice

• however, LTP can be rescued using D1 receptor-like agonists

reduced long-term depression ( J:122728 )

• long term depression (LTD) is impaired

• however, LTD can be rescued using D1 and D2 agonists and amphetamine

homeostasis/metabolism

decreased dopamine level ( J:122728 )

• the mean evoked dopamine overflow is significantly decreased in striatal slices from 2 to 3 month old mice compared to wild-type

• release of dopamine is decreased

• however, the number of D1 and D2 receptors is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 6		DOID:0060369	OMIM:605909	J:122728