About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3716639
Allelic
Composition
Pink1tm1Shn/Pink1tm1Shn
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Shn mutation (1 available); any Pink1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• catecholamine release is lower than in wild-type mice
• long term potential (LTP) induced by high frequency stimulation in the absence of magnesium is lower than in wild-type mice
• however, LTP can be rescued using D1 receptor-like agonists
• long term depression (LTD) is impaired
• however, LTD can be rescued using D1 and D2 agonists and amphetamine

homeostasis/metabolism
• the mean evoked dopamine overflow is significantly decreased in striatal slices from 2 to 3 month old mice compared to wild-type
• release of dopamine is decreased
• however, the number of D1 and D2 receptors is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 6 DOID:0060369 OMIM:605909
J:122728


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory