Analysis Tools
endocrine/exocrine glands
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• mutant beta cells show different excitability from control cells; whole-cell conductance is markedly decreased in Gja9-null beta cells
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• insulin release from beta cells in response to high glucose declines with a significantly longer time constant than in control cells; cells release insulin in response to a much wider glucose concentration than control cells do
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digestive/alimentary system
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• beta cells from mutants, heterozygotes, and wild-type exhibit similar cell capacitance, indicating similar cell size
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behavior/neurological
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• normal motor performance using an "Erasmus box" test
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• step time is significantly increased during conditioning in an "Erasmus box" test
• timing of responses worsens in the course of conditioning in an eye-blink conditioning test
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nervous system
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• Purkinje climbing fiber show both short and long latency responses in eye-blink tests unlike controls where only short latency responses are seen
• 60% show short latency, 34% show long latency, and 6% show both
• increased numbers of doublets during spontaneous activity in the awake state
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• more olivary cells likely to lack subthereshold oscillations in whole cell recordings
• subthreshold oscillations with slightly larger amplitudes than controls
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homeostasis/metabolism
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• insulin release from beta cells in response to high glucose declines with a significantly longer time constant than in control cells; cells release insulin in response to a much wider glucose concentration than control cells do
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