Phenotypes Associated with This Genotype

Genotype
MGI:3716170

• Allelic Composition: Tg(CD19-Tnfsf7)#Rvl/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:88620 )

decreased transitional stage B cell number ( J:88620 )

• transitional-1 B cells are reduced at 4 weeks of age and declining over time

• transitional-2 B cells decline after 6 to 8 weeks

decreased mature B cell number ( J:88620 )

• mature B cells are reduced at 4 weeks of age and declining over time

abnormal metallophilic macrophage morphology ( J:88620 )

• marginal metallophilic macrophages decline more gradually than marginal zone macrophages

abnormal spleen marginal zone morphology ( J:88620 )

• B cell follicles are reduced in size

abnormal spleen marginal zone macrophage morphology ( J:88620 )

• marginal zone macrophages decline in number at 5 weeks

immune system

decreased B cell number ( J:88620 )

decreased transitional stage B cell number ( J:88620 )

• transitional-1 B cells are reduced at 4 weeks of age and declining over time

• transitional-2 B cells decline after 6 to 8 weeks

decreased mature B cell number ( J:88620 )

• mature B cells are reduced at 4 weeks of age and declining over time

abnormal metallophilic macrophage morphology ( J:88620 )

• marginal metallophilic macrophages decline more gradually than marginal zone macrophages

abnormal spleen marginal zone morphology ( J:88620 )

• B cell follicles are reduced in size

abnormal spleen marginal zone macrophage morphology ( J:88620 )

• marginal zone macrophages decline in number at 5 weeks