Mouse Genome Informatics
hm
    Ins1tm1Jja/Ins1tm1Jja
NOD.129S2-Ins1tm1Jja
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Severe insulitis in Ins2tm1Jja/Ins2tm1Jja mice and lack of insulitis in Ins1tm1Jja/Ins1tm1Jja mice

immune system
• homozygotes are resistant to diabetes and insulitis development on the NOD background; whereas 13 of 15 wild-type NOD mice develop insulitis, only 1 of 19 homozygotes develop diabetes
• homozygous islets transplanted under the kidney capsule of recent onset NOD wild-type mice reversed the hyperglycemia and maintained euglycemia for a week or longer

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:85309