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Phenotypes Associated with This Genotype
Genotype
MGI:3716066
Allelic
Composition		 Fzd5tm1Cle/Fzd5tm1Cle
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd5tm1Cle mutation (1 available); any Fzd5 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
ectopic Paneth cells ( J:98680 )
• Paneth cells are randomly distributed in crypts and villi in mutants whereas they are localized to the base of crypts in wild-type mice
• highest number of mispositioned cells is found in the duodenum
• mispositioned cells contain no beta-catenin, and do not express cryptdin-1 mRNA, but contain lysozyme like normal Paneth cells

endocrine/exocrine glands
ectopic Paneth cells ( J:98680 )
• Paneth cells are randomly distributed in crypts and villi in mutants whereas they are localized to the base of crypts in wild-type mice
• highest number of mispositioned cells is found in the duodenum
• mispositioned cells contain no beta-catenin, and do not express cryptdin-1 mRNA, but contain lysozyme like normal Paneth cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory