Phenotypes Associated with This Genotype

Genotype
MGI:3715724

• Allelic Composition: Pfn2^tm1Wit/Pfn2^tm1Wit
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle number ( J:122603 )

• mice exhibit a 23% increase in the number of physically docked vesicles

abnormal striatum morphology ( J:122603 )

• mice striatum have a 20% shift in the length distribution of the active zones towards higher values as well as a 30% increase in the number of perforated synapses and multiple site boutons

abnormal excitatory postsynaptic currents ( J:122603 )

• spontaneous excitatory postsynaptic currents are increased following application of 4-aminopyridine (4-AP)

abnormal miniature excitatory postsynaptic currents ( J:122603 )

• the frequency of miniature events is slightly higher

decreased paired-pulse facilitation ( J:122603 )

behavior/neurological

increased exploration in new environment ( J:122603 )

abnormal response to novel object ( J:122603 )

• mice visit novel object more often than wild-type mice

cellular

abnormal synaptic vesicle number ( J:122603 )

• mice exhibit a 23% increase in the number of physically docked vesicles

abnormal cell physiology ( J:122603 )

• an increase in F-actin levels is not seen following stimulation with 20mM KCL for 60s as in wild-type mice