Mouse Genome Informatics
ht
    Thrbtm1Df/Thrbtm1.1Syc
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• begin to die at about 5 months of age; 50% die by around 11 months of age and none survive beyond 16 months of age

endocrine/exocrine glands
• 10- and 41-fold increase in the size of thyroid glands at 3-6 months of age and 12-15 months of age, respectively

respiratory system
• respiratory distress due to the compression of the trachea by he enlarged thyroid glands

tumorigenesis
• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes

Mouse Models of Human Disease
OMIM IDRef(s)
Thyroid Carcinoma, Follicular; FTC 188470 J:92629