Phenotypes Associated with This Genotype

Genotype
MGI:3715718

• Allelic Composition: Thrb^tm1Df/Thrb^tm1.1Syc
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92629 )

• begin to die at about 5 months of age; 50% die by around 11 months of age and none survive beyond 16 months of age

endocrine/exocrine glands

enlarged thyroid gland ( J:92629 )

• 10- and 41-fold increase in the size of thyroid glands at 3-6 months of age and 12-15 months of age, respectively

increased thyroid carcinoma incidence ( J:92629 )

• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes

respiratory system

respiratory distress ( J:92629 )

• respiratory distress due to the compression of the trachea by he enlarged thyroid glands

neoplasm

increased thyroid carcinoma incidence ( J:92629 )

• spontaneously develop follicular thyroid carcinoma through the pathological progression of hyperplasia, capsular and vascular invasion, anaplasia, and eventually metastasis to the lung but not the lymph nodes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid gland follicular carcinoma		DOID:3962	OMIM:188470	J:92629