Phenotypes Associated with This Genotype

Genotype
MGI:3715644

• Allelic Composition: Cr2^tm1Hmo/Cr2^tm1Hmo
• Genetic Background: B6.129S7-Cr2^tm1Hmo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:78241 )

• reduced mucosal injury and little change in villus height in intestines after mesenteric ischemia and reperfusion

• no significant depositions of IgM, IgG or C3 observed

• pretreatment with IgM or a combination of IgM and IgG restores injury response to ischemia reperfusion

renal/urinary system

renal/urinary system phenotype ( J:103238 )

N • no significant effect on renal ischemia reperfusion injury

immune system

increased susceptibility to bacterial infection ( J:94855 )

• mice are more susceptible to pneumococcal infection than controls

• when challenged with a PspA^- bacterial strain, mice have a 10-fold higher burden 4 hours after infection

• mice on average die 3.5 days after infection compared to none in wild-type controls

• only 20% of mice survive infection while all wild-type controls survive

• only 12% of mice survive infection with a more virulent PspA⁺ strain compared to 42% of controls