Phenotypes Associated with This Genotype

Genotype
MGI:3715465

• Allelic Composition: Thra^tm1Syc/Thra⁺
• Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:73446 )

• 30% of mutants die; of these, 83% and 96% die by 6 weeks and 11 weeks of age, respectively

growth/size/body

decreased body weight ( J:73446 )

• by 4 weeks of age, weight is about 30% and 40% less in females and males, respectively, than in wild-type

decreased body length ( J:73446 )

• by 4 weeks of age, body length is 15% and 17% shorter in females and males, respectively, than in wild-type

homeostasis/metabolism

increased circulating triiodothyronine level ( J:73446 )

• 15% increase in the mean total T3 concentration

increased circulating thyroid-stimulating hormone level ( J:73446 )

• 1.7-fold higher TSH concentration

endocrine/exocrine glands

decreased activity of thyroid gland ( J:73446 )

• mild thyroid failure

• however, follicular morphology is normal and no lymphoid infiltration is seen in the thyroid glands

reproductive system

reduced fertility ( J:73446 )

• reduced fertility as indicated by decreases in the frequencies of pregnancy and the litter size

reduced female fertility ( J:73446 )

♀

decreased litter size ( J:73446 )

• litter size is reduced from 10-12 to 3-5 per litter

reduced male fertility ( J:73446 )

♂