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Phenotypes Associated with This Genotype
Genotype
MGI:3715443
Allelic
Composition
Mdm2tm1Bay/Mdm2tm1Mep
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Bay mutation (1 available); any Mdm2 mutation (53 available)
Mdm2tm1Mep mutation (1 available); any Mdm2 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• number of offspring is less than the expected 25%; percentage of female offspring is 15-16%

growth/size/body
• at 5 weeks of age, a 15-20% reduction in body weight is observed relative to wild-type mice

hematopoietic system
• thymus wet weight is significantly less than in wild-type; weight is decreased 2.5-fold
• decreased number of lymphoid cells; thymi are hypocellular
• 87% reduction in number of more mature B220+ IgM+ B cells
• at 5-6 weeks, mice exhibit mild anemia
• number of lymphoid cells is decreased 7-fold; mutants have only ~50% as many bone marrow cells as wild-type mice at 5-6 weeks
• red blood cell count is 82% of wild-type; 2-fold decrease in number of erythrocytes is found at 5-6 weeks
• WBC count is only 30% of wild-type
• 1.2-fold decrease
• concentration of neutrophils is 60% of wild-type value
• lymphocyte concentration is reduced to 37% of wild-type
• 40% reduction in CD43+ B220+ immature B cells in bone marrow relative to wild-type
• reduced to 40% of wild-type number
• thymocyte number is 5% of wild-type
• number of mature, double-negative thymocytes is reduced by >80% compared to wild-type
• double positive thymocyte numbers are reduced in relative proportion from 40% in wild-type to 20% in mutants at 5-6 weeks
• spleen wet weight is significantly less than in wild-type
• decreased number of lymphoid cells

immune system
• thymus wet weight is significantly less than in wild-type; weight is decreased 2.5-fold
• decreased number of lymphoid cells; thymi are hypocellular
• 87% reduction in number of more mature B220+ IgM+ B cells
• WBC count is only 30% of wild-type
• 1.2-fold decrease
• concentration of neutrophils is 60% of wild-type value
• lymphocyte concentration is reduced to 37% of wild-type
• 40% reduction in CD43+ B220+ immature B cells in bone marrow relative to wild-type
• reduced to 40% of wild-type number
• thymocyte number is 5% of wild-type
• number of mature, double-negative thymocytes is reduced by >80% compared to wild-type
• double positive thymocyte numbers are reduced in relative proportion from 40% in wild-type to 20% in mutants at 5-6 weeks
• spleen wet weight is significantly less than in wild-type
• decreased number of lymphoid cells

liver/biliary system
• liver wet weight is less than in wild-type

renal/urinary system
• kidney wet weight is less than in wild-type

cellular
• an increase in G1 arrest function is seen, with number of S-phase cells 72% of wild-type MEFs
• exposure to 10 Gy of radiation results in 100% mortality within 7-9 days of treatment, compared to ~50% mortality in wild-type mice between 12 and 22 days after treatment
• MEFs in culture show decreased rate of proliferation compared to wild-type or Mdm2-heterozygous cells

endocrine/exocrine glands
• thymus wet weight is significantly less than in wild-type; weight is decreased 2.5-fold
• decreased number of lymphoid cells; thymi are hypocellular
• thymocyte number is 5% of wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory