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Phenotypes Associated with This Genotype
Genotype
MGI:3715440
Allelic
Composition
Rd3rd3/Rd3rd3
Genetic
Background
RBF/DnJ-Rd3rd3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rd3rd3 mutation (4 available); any Rd3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• after 3 weeks, the outer nuclear layer is reduced
• however, mice have normal eye morphology prior to 3 weeks
• after 3 weeks, the photoreceptor layer is reduced
• however, mice have normal eye morphology prior to 3 weeks
• at 4 weeks rods are no longer detected
• by 8 weeks no photoreceptors are present
• at week 4, the b-wave amplitude is 25% of that in wild-type mice
• by 6 weeks, a signal is barely detectable even with the brightest stimuli

nervous system
• at 4 weeks rods are no longer detected
• by 8 weeks no photoreceptors are present

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Leber congenital amaurosis 12 DOID:0110080 OMIM:610612
J:202634


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory