Phenotypes Associated with This Genotype

Genotype
MGI:3715341

• Allelic Composition: Ank^tm1Kng/Ank⁺; Tg(Gdf5-cre,-ALPP)1Kng/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal cementum morphology ( J:122727 )

• expanded layer of cementum

abnormal joint morphology ( J:122727 )

• 64 of 84 mutants have abnormal joints

• ectopic cartilage depositions occurs similar to in Ank^tm1.1Kng homozygotes

• ectopic mineral deposition in joints

abnormal articular cartilage morphology ( J:122727 )

• articular cartilage of joints is disrupted

fused joints ( J:122727 )

• ankylosis, however joint fusion is delayed compared to Ank^ank or Ank^tm1.1Kng homozygotes

decreased joint mobility ( J:122727 )

• at 9 weeks, mice develop decreased mobility in the distal joints

craniofacial

abnormal cementum morphology ( J:122727 )

• expanded layer of cementum

growth/size/body

abnormal cementum morphology ( J:122727 )

• expanded layer of cementum