Analysis Tools
mortality/aging
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• mice die at 6 months of age with all of their joints in the limbs and axial skeleton became immobilized
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skeleton
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• the calcified materials surrounding the neck and tooth of all 12 molars is increased
• the neck thickness relative to the enamel cap width is increased
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• at 12 weeks, enlargement of the cementum
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• bone volume is significantly increased and increases in severity with time
ectopic cartilage depositions occurs
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fused joints
(
J:122727
)
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• severe joint ankylosis
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• widespread joint mineralization
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• at 3 to 4 weeks, mice are unable to grasp with their forepaws due to loss of joint mobility
• joint mobility is decreased at 6 weeks and is more severe at 12 weeks similar to in Ankank homozygotes
• reduction in joint mobility in the forelimb joints is more severe than in the hindlimbs and distal joints in the hindlimbs are more severely affected than proximal joints
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behavior/neurological
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• at 3 to 4 weeks, mice begin to walk with a stiff, flat-footed gait
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craniofacial
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• the calcified materials surrounding the neck and tooth of all 12 molars is increased
• the neck thickness relative to the enamel cap width is increased
|
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• at 12 weeks, enlargement of the cementum
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growth/size/body
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• the calcified materials surrounding the neck and tooth of all 12 molars is increased
• the neck thickness relative to the enamel cap width is increased
|
|
• at 12 weeks, enlargement of the cementum
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