Analysis Tools
immune system
|
• deficient splenocytes injected into wild-type recipients which overexpress Th1 cytokines show lower efficiency in migrating to the spleen
• in a model of aseptic peritonitis, seven days after peritonitis induction, mutants have lower numbers of inflammatory cells in the peritoneal cavity compared to wild-type mice
|
|
• in an aseptic peritonitis model, neutrophils display a defect in exiting the circulation into the peritoneal cavity; neutrophils are present in greater numbers in circulation of mutant animals compared to wild-type in aseptic peritonitis model
• after induction of peritonitis in Pscdbp-deficient mice, a limited reduction in circulating WBCs is observed compared to a 50% decrease in wild-type controls
|
|
• reduced circulating WBCs in animals >6 months of age, with reduction of neutrophilic and monocytic fractions
|
|
• reduced numbers of virus specific CTLs are observed infiltrating the tumors in null mice
|
|
• lymphocyte numbers in tumor-draining lymph nodes are significantly reduced compared to controls mice, with fewer leukocytes infiltrating the tumors
|
hematopoietic system
|
• deficient splenocytes injected into wild-type recipients which overexpress Th1 cytokines show lower efficiency in migrating to the spleen
• in a model of aseptic peritonitis, seven days after peritonitis induction, mutants have lower numbers of inflammatory cells in the peritoneal cavity compared to wild-type mice
|
|
• in an aseptic peritonitis model, neutrophils display a defect in exiting the circulation into the peritoneal cavity; neutrophils are present in greater numbers in circulation of mutant animals compared to wild-type in aseptic peritonitis model
• after induction of peritonitis in Pscdbp-deficient mice, a limited reduction in circulating WBCs is observed compared to a 50% decrease in wild-type controls
|
|
• reduced circulating WBCs in animals >6 months of age, with reduction of neutrophilic and monocytic fractions
|
|
• reduced numbers of virus specific CTLs are observed infiltrating the tumors in null mice
|
neoplasm
|
• in null mice injected with Moloney murine sarcoma/Moloney murine leukemia virus, a higher (but nonsignificant) levelo of tumor incidence is observed (87% vs 70% in controls); mutant animals develop significantly larger sarcomas than wild-type mice
• regression of tumors occurs with slower kinetics than in wild-type controls
|
cellular
|
• deficient splenocytes injected into wild-type recipients which overexpress Th1 cytokines show lower efficiency in migrating to the spleen
• in a model of aseptic peritonitis, seven days after peritonitis induction, mutants have lower numbers of inflammatory cells in the peritoneal cavity compared to wild-type mice
|
|
• in an aseptic peritonitis model, neutrophils display a defect in exiting the circulation into the peritoneal cavity; neutrophils are present in greater numbers in circulation of mutant animals compared to wild-type in aseptic peritonitis model
• after induction of peritonitis in Pscdbp-deficient mice, a limited reduction in circulating WBCs is observed compared to a 50% decrease in wild-type controls
|
