Phenotypes Associated with This Genotype

Genotype
MGI:3715229

• Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺; Snai1^tm1Grid/Snai1^tm2Grid
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:111702 )

• embryos survive as late as E9.5 when death occurs due to severe vascular defects

embryo

increased allantois apoptosis ( J:111702 )

• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5

abnormal direction of embryo turning ( J:111702 )

• at E9.5, 46% of mutant embryos show reversed axial rotation compared to no control embryos

abnormal primitive streak morphology ( J:111702 )

abnormal allantois morphology ( J:111702 )

• at E8.5, poorly formed allantois with failure to fuse dorsally with the chorion is observed; there is a prominent dorsal bulge extruding dorsally. close to primitive streak

cardiovascular system

abnormal cardiac outflow tract development ( J:111702 )

• at E9.5, some mutant embryos display reversed position of the atrioventricular canal and outflow tract

abnormal heart development ( J:111702 )

• in 23% of embryos at E9.5, there is a vertical heart tube with ambiguous looping direction

abnormal fetal atrioventricular canal morphology ( J:111702 )

• at E9.5, in some embryos canal is reversed with outflow tract

abnormal direction of heart looping ( J:111702 )

• in 40% of mutant embryos, heart looping is reversed, whereas 37% show normal looping and remainder are ambiguous

cellular

increased allantois apoptosis ( J:111702 )

• numerous apoptotic cells are observed in the posterior bulge of allantois in mutant embryos at E8.5