Phenotypes Associated with This Genotype

Genotype
MGI:3715200

• Allelic Composition: Mx1^s1/Mx1^s1
• Genetic Background: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following infection with Thogoto virus, 9 of 10 mice die despite treatment with an interferon inducer, poly(I)-poly(C)

• following intraperitoneal infection with Thogoto virus, 7 of 7 mice die

immune system

abnormal peritoneal macrophage morphology ( J:23752 )

• after 96 hours of Thogoto virus infection in culture, peritoneal microphages become round and detach from culture dishes

abnormal susceptibility to infection ( J:120938 )

• LD50 for hvPR8 is about 10 plaque forming units

• IFN treatment is ineffective at decreasing susceptibility to hvPR8

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following infection with Thogoto virus, 9 of 10 mice die despite treatment with an interferon inducer, poly(I)-poly(C)

• following intraperitoneal infection with Thogoto virus, 7 of 7 mice die

hematopoietic system

abnormal peritoneal macrophage morphology ( J:23752 )

• after 96 hours of Thogoto virus infection in culture, peritoneal microphages become round and detach from culture dishes