Phenotypes Associated with This Genotype

Genotype
MGI:3715018

• Allelic Composition: Cdx2^tm1Mmt/Cdx2⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:47050 )

• runted

skeleton

abnormal rib morphology ( J:47050 )

• malformed

vertebral transformation ( J:47050 )

• anterior homeotic shift of vertebrae

digestive/alimentary system

abnormal cecum morphology ( J:47050 )

• numerous viliform structures aligned in rows

• epithelium containing enterocytes and a few goblet cells

• anteriorization of epithelium

abnormal colon morphology ( J:47050 )

• numerous viliform structures aligned in rows

• villi are structurally similar to those in ileum but extending from colonic type crypts

• epithelium containing enterocytes and a few goblet cells

• anteriorization of epithelium

colon polyps ( J:47050 )

• in proximal colon

• benign in nature

• up to 8 mm in diameter

• up to 10/mouse at 3 months of age

increased colon hamartoma incidence ( J:47050 )

• colonic polyps similar to hamartomas but lacking goblet or paneth cells

neoplasm

increased colon hamartoma incidence ( J:47050 )

• colonic polyps similar to hamartomas but lacking goblet or paneth cells