Phenotypes Associated with This Genotype

Genotype
MGI:3714946

• Allelic Composition: Pax2^tm1Pgr/Pax2^tm1Pgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal cochlea morphology ( J:119574 )

• at E17.5, paintfilling indicates that a cochlea-like structure is present but it is severely malformed

abnormal inner ear vestibule morphology ( J:119574 )

• at E17.5, the saccule and utricle are found in a large single chamber without subdivision

• however, all three semicircular canals and ampullae are present

abnormal utricle morphology ( J:119574 )

abnormal vestibular saccule morphology ( J:119574 )

abnormal endolymphatic duct morphology ( J:119574 )

• at E17.5, no normal endolymphatic duct is observed