Mouse Genome Informatics
hm
    Apoetm1Unc/Apoetm1Unc
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
cardiovascular system
• fatty streaks with foam cells are found in the proximal aorta of 3-8 month old mice fed normal chow (J:16573)
• the foam cells are often adjacent to valve attachment sites and can form multi-layers (J:16573)
• lesions get bigger with age and near total occlusion at the entrance of a coronary artery can be observed at 8 months of age (J:16573)
• 75% of mice develop lesions in the aortic arch with most females and some males having calcification within the lesions (J:40136)
• aortic cartilaginous metaplasia is noted in the most severely affected mice (J:40136)
• greater than in wild-type (J:80689)

homeostasis/metabolism
• mean HDL levels (33 mg/dl) are 45% of that found in controls
• mean total cholesterol levels are elevated about 5-fold over wild-type to 434 mg/dl (J:16573)
• total cholesterol levels are about 4-fold higher than controls with a mean of 379 mg/dl (J:40136)
• relative to wild-type (J:80689)
• mice have elevated levels of LDL in the blood
• the majority of lipoprotein particles in the blood are in the VLDL size range
• circulating triglyceride levels are 123 mg/dl compared to 73 mg/dl in controls (J:16573)
• relative to wild-type (J:80689)
• relative to wild-type
• amount of PGE2 in aortas is 4X higher than in controls
• PGE2 level doubles on a high fat diet

nervous system
• elevated cholesterol in the exofacial leaflet of the synaptic plasma membrane but not so high as for Ldlr deficient mice
• cholesterol levels in the cytofacial leaflet are reduced
• astrocytes secrete less phospholipids or free cholesterol compared to wild-type astrocytes

immune system
• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding

respiratory system
• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:16573