Phenotypes Associated with This Genotype

Genotype
MGI:3714936

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:41510 , J:80689 , J:40136 , J:16573 )

• mice exhibit atherosclerotic lesions in the aorta and aortic root (J:41510)

• extent of atherosclerosis correlates with plasma cholesterol levels (J:41510)

• greater than in wild-type (J:80689)

• 75% of mice develop lesions in the aortic arch with most females and some males having calcification within the lesions (J:40136)

• aortic cartilaginous metaplasia is noted in the most severely affected mice (J:40136)

• fatty streaks with foam cells are found in the proximal aorta of 3-8 month old mice fed normal chow (J:16573)

• the foam cells are often adjacent to valve attachment sites and can form multi-layers (J:16573)

• lesions get bigger with age and near total occlusion at the entrance of a coronary artery can be observed at 8 months of age (J:16573)

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:16573 )

• mean HDL levels (33 mg/dl) are 45% of that found in controls

increased circulating cholesterol level ( J:41510 , J:80689 , J:40136 , J:16573 )

• plasma cholesterol levels increase significantly with time (J:41510)

• relative to wild-type (J:80689)

• total cholesterol levels are about 4-fold higher than controls with a mean of 379 mg/dl (J:40136)

• mean total cholesterol levels are elevated about 5-fold over wild-type to 434 mg/dl (J:16573)

increased circulating LDL cholesterol level ( J:16573 )

• mice have elevated levels of LDL in the blood

increased circulating VLDL cholesterol level ( J:41510 , J:16573 )

• very high levels of VLDL cholesterol (J:41510)

• the majority of lipoprotein particles in the blood are in the VLDL size range (J:16573)

increased circulating triglyceride level ( J:80689 , J:16573 )

• relative to wild-type (J:80689)

• circulating triglyceride levels are 123 mg/dl compared to 73 mg/dl in controls (J:16573)

hyperlipidemia ( J:80689 )

• relative to wild-type

increased prostaglandin level ( J:125376 )

• amount of PGE2 in aortas is 4X higher than in controls

• PGE2 level doubles on a high fat diet

nervous system

abnormal astrocyte physiology ( J:58019 )

• astrocytes secrete less phospholipids or free cholesterol compared to wild-type astrocytes

abnormal synapse morphology ( J:43043 )

• elevated cholesterol in the exofacial leaflet of the synaptic plasma membrane but not so high as for Ldlr deficient mice

• cholesterol levels in the cytofacial leaflet are reduced

immune system

lung inflammation ( J:83615 )

• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding

respiratory system

lung inflammation ( J:83615 )

• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding

cellular

abnormal astrocyte physiology ( J:58019 )

• astrocytes secrete less phospholipids or free cholesterol compared to wild-type astrocytes