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Phenotypes Associated with This Genotype
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (23 available); any Apoe mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• fatty streaks with foam cells are found in the proximal aorta of 3-8 month old mice fed normal chow (J:16573)
• the foam cells are often adjacent to valve attachment sites and can form multi-layers (J:16573)
• lesions get bigger with age and near total occlusion at the entrance of a coronary artery can be observed at 8 months of age (J:16573)
• 75% of mice develop lesions in the aortic arch with most females and some males having calcification within the lesions (J:40136)
• aortic cartilaginous metaplasia is noted in the most severely affected mice (J:40136)
• mice exhibit atherosclerotic lesions in the aorta and aortic root (J:41510)
• extent of atherosclerosis correlates with plasma cholesterol levels (J:41510)
• greater than in wild-type (J:80689)

• mean HDL levels (33 mg/dl) are 45% of that found in controls
• mean total cholesterol levels are elevated about 5-fold over wild-type to 434 mg/dl (J:16573)
• total cholesterol levels are about 4-fold higher than controls with a mean of 379 mg/dl (J:40136)
• plasma cholesterol levels increase significantly with time (J:41510)
• relative to wild-type (J:80689)
• mice have elevated levels of LDL in the blood
• the majority of lipoprotein particles in the blood are in the VLDL size range (J:16573)
• very high levels of VLDL cholesterol (J:41510)
• circulating triglyceride levels are 123 mg/dl compared to 73 mg/dl in controls (J:16573)
• relative to wild-type (J:80689)
• relative to wild-type
• amount of PGE2 in aortas is 4X higher than in controls
• PGE2 level doubles on a high fat diet

nervous system
• elevated cholesterol in the exofacial leaflet of the synaptic plasma membrane but not so high as for Ldlr deficient mice
• cholesterol levels in the cytofacial leaflet are reduced
• astrocytes secrete less phospholipids or free cholesterol compared to wild-type astrocytes

immune system
• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding

respiratory system
• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory