cardiovascular system
• fatty streaks with foam cells are found in the proximal aorta of 3-8 month old mice fed normal chow
(J:16573)
• the foam cells are often adjacent to valve attachment sites and can form multi-layers
(J:16573)
• lesions get bigger with age and near total occlusion at the entrance of a coronary artery can be observed at 8 months of age
(J:16573)
• 75% of mice develop lesions in the aortic arch with most females and some males having calcification within the lesions
(J:40136)
• aortic cartilaginous metaplasia is noted in the most severely affected mice
(J:40136)
• mice exhibit atherosclerotic lesions in the aorta and aortic root
(J:41510)
• extent of atherosclerosis correlates with plasma cholesterol levels
(J:41510)
• greater than in wild-type
(J:80689)
|
homeostasis/metabolism
• mean HDL levels (33 mg/dl) are 45% of that found in controls
|
• mean total cholesterol levels are elevated about 5-fold over wild-type to 434 mg/dl
(J:16573)
• total cholesterol levels are about 4-fold higher than controls with a mean of 379 mg/dl
(J:40136)
• plasma cholesterol levels increase significantly with time
(J:41510)
• relative to wild-type
(J:80689)
|
• mice have elevated levels of LDL in the blood
|
• the majority of lipoprotein particles in the blood are in the VLDL size range
(J:16573)
• very high levels of VLDL cholesterol
(J:41510)
|
• circulating triglyceride levels are 123 mg/dl compared to 73 mg/dl in controls
(J:16573)
• relative to wild-type
(J:80689)
|
• relative to wild-type
|
• amount of PGE2 in aortas is 4X higher than in controls
• PGE2 level doubles on a high fat diet
|
nervous system
• elevated cholesterol in the exofacial leaflet of the synaptic plasma membrane but not so high as for Ldlr deficient mice
• cholesterol levels in the cytofacial leaflet are reduced
|
• astrocytes secrete less phospholipids or free cholesterol compared to wild-type astrocytes
|
immune system
• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding
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respiratory system
• isolated small foci of mononuclear cells are present in lung after 6 weeks of high-fat feeding
|