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Phenotypes Associated with This Genotype
Genotype
MGI:3714933
Allelic
Composition		 Gad1tm1Oba/Gad1tm1Oba
Gad2tm1Oba/Gad2tm1Oba
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1Oba mutation (1 available); any Gad1 mutation (65 available)
Gad2tm1Oba mutation (1 available); any Gad2 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased gamma-aminobutyric acid level ( J:102619 )
• GABA content in double nulls is very low (0.02% that of Gad2-heterozygous, Gad1-null mice)

mortality/aging
neonatal lethality, complete penetrance ( J:102619 )
• mice die shortly after birth

craniofacial

nervous system
nervous system phenotype ( J:102619 )
N
• mutant and wild-type brains are similar in size and morphology; no histological abnormalities are observed in neocortex, cerebellum or hippocampus
• neurons and Purkinje cells develop normally in mutants, with normal axon and dendrite formation

digestive/alimentary system

growth/size/body
cleft palate ( J:102619 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory