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Phenotypes Associated with This Genotype
Genotype
MGI:3714931
Allelic
Composition		 Gad1tm1Oba/Gad1+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gad1tm1Oba mutation (1 available); any Gad1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased gamma-aminobutyric acid level ( J:40978 )
• GABA levels in cortex at P0.5 are 65% of wild-type; similar degree of reduction is observed at E14.5
decreased glutamate decarboxylase activity ( J:40978 )
• glutamic acid decarboxylase activity in cerebral cortex is 62% of wild-type littermates at P0.5; similar reduction is observed at E14.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory