Phenotypes Associated with This Genotype

Genotype
MGI:3714774

• Allelic Composition: Noct^tm1Bjc/Noct^tm1Bjc
• Genetic Background: B6.129S2-Noct^tm1Bjc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Noct^tm1Bjc/Noct^tm1Bjc mice exhibit a diet-dependent lean phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:122301 )

• mice do not gain weight as much as wild-type when mice are fed a high fat diet

increased circulating glucose level ( J:122301 )

• when fed a standard diet, circulating glucose level is slightly increased

impaired glucose tolerance ( J:122301 )

• on a high fat diet, glucose tolerance is less than wild-type

increased insulin sensitivity ( J:122301 )

• when fed a standard diet, mice have increased insulin sensitivity

• however, insulin sensitivity after being fed a high fat diet is comparable to that in wild-type

liver/biliary system

decreased susceptibility to hepatic steatosis ( J:122301 )

growth/size/body

decreased susceptibility to diet-induced obesity ( J:122301 )

• mice do not gain weight as much as wild-type when mice are fed a high fat diet